Part 2 - Neuromodulator Education

This page contains educational resources specific to the neuromodulators and fillers available at Peach Skin Clinic. This page is not meant to diagnose or recommend. If you have any questions, please contact us at one our facilities. 


Concepts of Product

The main objective of a neurmodulator medication like Botox Cosmetic or Dysport is to causes paralysis and/or diminish muscle movement. Through this action, the tissue will be relaxed and the lines that are formed are eliminated or softened. 

Muscle movement is caused because of the nerves that are triggered at the neuromuscular junction (NMJ). The trigger in this instance is a chemical substance called acetylcholine which is a protein based chin that works as a neurotransmitter. When a medication like Botox and Dysport are introduced to the NMJ via an injection, it blocks this chemical communication, which ultimately prevents the muscle from contracting. 

Botulinum neurotoxins are polypeptides. These polypeptides are the protein molecules that make up the substance in Botox and Dysport. Patients and aesthetic professionals may notice that a protein antibody can be built that will cause Botox and or Dysport to not yield results. 

 
 

Preparation, mixing, and storage

Both Botox Cosmetic and Dysport vials arrives freeze dried to the bottom of the vial. At first site, it may appear empty. Botox and Dysport are recommended to be kept at -5 C or lower before reconstitution, although some studies have shown that warmer temperatures does not affect the medication potency.  

When Botox Cosmetic and Dysport arrives, it is on dry ice and the aesthetic professional must "mix" the dried frozen powder prior to injection to a patient. The mixing and dilution process includes the introduction of preservative free saline solution into the vial. The dilution rate and the amount of saline is typically left up to the health professional. The mos common dilution amounts are 1ml, 2ml, and 4ml. The more dilution the more volume will be needed to accomplish the same potency. Studies have shown that the greater the dilution amount the more diffusion the medication will experience. This can cause the medication to migrate to unintended areas.

Both Botox and Dysport are recommended to be used within 4 hours of reconstitution. If health professional must store medication , then it is recommended to be stored in pharmaceutical refrigeration.  

 

 
 

Indications for Botox and Dysport

  • Upper third of the face (frontalis, corrugulator supercilii and procerus, orbicularis oculi muscle). 
  • Middle third of the face (levator labii superioris alaequenasi, nasalis)
  • After facial cosmetic surgery
  • Abnormal muscle hypertrophy
  • In combination with other cosmetic procedures
  • Facial nerve disorders
  • Parotid gland fistula
  • Headaches
  • Temporomandibular joint dysfunction
  • Hyperhidrosis
  • Upper eyelid asymmetry

Tips on injection for health professionals

  • Always wear gloves
  • Clean the target area skin well
  • Make sure that the needle is attached to the TB syringe
  • For beginners, marking the skin may help to visualize the specific areas to be injected.